The best way to figure out a problem registry entry that should not be modified is to correct all invalid registry keys found by Registry First Aid, then re-install the problem software, be sure that it works and scan the registry with Registry First Aid again. More likely, the program will find some new invalid registry entries and some of them will belong to the problem software.
From this moment you can correct every single invalid entry (with creating separate backup files) and test your software after every single correction. If the program doesn't work after last correction then that registry entry should not be modified. Restore it from the last created backup .reg file. Be sure that the program works fine again and add that registry key into the Excluded list.
In this way you will able to find one or more registry entries that should not be modified. Add those entries into the excluded list using the right-click pop-up menu over the selected entry.
If you feel you don't want to take the time to do this deep test, you can simply add into the exclusion lists all of the new found registry entries after re-installing your problem software.
-OR-
HKEY_LOCAL_MACHINE\Software\your_problem_program_name\....
Unselect all of the found entries, pick only this entry and make changes
to the registry, by creating an individual backup file like C:\Program Files\...\trouble_1.reg
Then run your program and check if it functions properly. If it runs OK
then restore that corrected entry and try to find another problem entry
using the previous method. When you find the problem entry (after
correcting it, your favorite program stops working), add the entry to the
Exclude
List.After that run the registry scan, make registry changes and be sure that your program works OK (the found problem entry will be excluded from the registry scanning).
This problem finding algorithm is useful for all faults that may appear after repairing the registry using Registry First Aid.
Please, also take the time to send your found excluded registry entries with a detailed description of the problem (what applications do not start, do not work properly, etc.) to support. This will help us to help you to avoid the same problem with future versions of the program.
Running Registry First Aid once a week in the future will decrease the number of invalid registry entries, and correction will not be a problem.